Article

Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer’s disease

2022-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a multifactorial disorder driven by abnormal amyloid β-peptide (Aβ) levels. To identify new druggable pathways involved in the Aβ cascade we here investigated the AD pathophysiological role of the presenilin-like intramembrane protease signal peptide peptidase-like 2b (SPPL2b). Aβ42 induced a biphasic modulation of SPPL2b expression in human cell lines and ex vivo mou...

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Literature Corpus work: 610d51be-ccb2-5d00-8af8-6c8a3f610697
DOI: 10.1101/2022.10.24.513473

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Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer’s diseaseDOI 10.1101/2022.10.24.513473Read

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