Article
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Nature immunology - 1 Dec 2021
Behrens Gesine, Edelmann Stephanie L, Raj Timsse, Kronbeck Nina, Monecke Thomas, Davydova Elena, Wong Elaine H, Kifinger Lisa, Giesert Florian, Kirmaier Martin E, Hohn Christine, de Jonge Laura S, Pisfil Mariano Gonzalez, Fu Mingui, Theurich Sebastian, Feske Stefan, Kawakami Naoto, Wurst Wolfgang, Niessing Dierk, Heissmeyer Vigo
Abstract excerpt
Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory target messenger RNAs to maintain immune homeostasis. Either the sanroque mutation in Roquin-1 or loss of Regnase-1 cause systemic lupus erythematosus-like phenotypes. Analyzing mice with T cells that lack expression of Roquin-1, its paralog Roquin-2 and Regnase-1 proteins, we detect overlapping or unique phenotypes by...
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