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Article

AIRE-mutations and autoimmune disease.

Current opinion in immunology - 1 Dec 2016

Bruserud Øyvind, Oftedal Bergithe E, Wolff Anette B, Husebye Eystein S

Abstract excerpt

The gene causing the severe organ-specific autoimmune disease autoimmune polyendocrine syndrome type-1 (APS-1) was identified in 1997 and named autoimmune regulator (AIRE). AIRE plays a key role in shaping central immunological tolerance by facilitating negative selection of T cells in the thymus, building the thymic microarchitecture, and inducing a specific subset of regulatory T cells. So far, about 100...

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Source

Identifiers

PMID: 27504588
DOI: 10.1016/j.coi.2016.07.003

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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