Article

An immunocompetent osteoblastic model of mammary cancer bone metastasis established by syngeneic intratibial injection of PyMT mammary carcinoma cells in FVB/N mice

2026-07-09

Abstract excerpt

Osteoblastic bone metastasis, in which disseminated tumor cells drive net bone formation, is a clinically distinct and mechanistically underexplored form of skeletal disease that is enriched in hormone receptor-positive breast cancers. Preclinical models of bone metastasis from breast cancer predominantly rely on immunodeficient hosts inoculated with osteolytic human breast cancer cell lines, limiting the study of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6106bc8b-208b-556a-9373-92fa37a95d60
DOI: 10.64898/2026.07.08.737245

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An immunocompetent osteoblastic model of mammary cancer bone metastasis established by syngeneic intratibial injection of PyMT mammary carcinoma cells in FVB/N miceDOI 10.64898/2026.07.08.737245Read

Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases.Semantic proximity Read

Bone marrow B cell collapse promotes bone metastasis in breast cancerSemantic proximity Read

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancerSemantic proximity Read

Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model.Semantic proximity Read

Bioengineered human bone-mimetic niche compositions regulate breast cancer cell quiescence and therapy responseSemantic proximity Read

Tissue-Engineered Bone Serves as a Target for Metastasis of Human Breast Cancer in a Mouse ModelSemantic proximity Read

Osteomimicry: how tumor cells try to deceive the bone.Semantic proximity Read

Establishment and characterization of a C57BL/6 mouse model of bone metastasis of breast cancer.Semantic proximity Read

Generation of induced tumor-suppressing cells from osteoblasts and mesenchymal stem cellsSemantic proximity Read

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-β–Deficient Mouse Mammary CarcinomasSemantic proximity Read

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice.Semantic proximity Read

A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis.Semantic proximity Read