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Article

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018

Devignes Claire-Sophie, Aslan Yetki, Brenot Audrey, Devillers Audrey, Schepers Koen, Fabre Stéphanie, Chou Jonathan, Casbon Amy-Jo, Werb Zena, Provot Sylvain

Abstract excerpt

Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in cancer metastasis is unknown. Here, we show that osteoprogenitor cells (OPCs) are located in hypoxic niches in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29339479
DOI: 10.1073/pnas.1718009115
PMCID: PMC5798374

Genes

CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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