Article

Prediction and validation of host cleavage targets of SARS-CoV-2 3C-like protease

2022-01-19

Abstract excerpt

How SARS-CoV-2 causes the observed range of clinical manifestations and disease severity remains poorly understood. SARS-CoV-2 encodes for two proteases (3CLPro and PLPro), vital for viral production, but also promiscuous with respect to host protein targets, likely contributing to the range of disease. Pharmacological inhibition of the 3C-like3 protease has revealed remarkable reduction in hospitalization and dea...

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Literature Corpus work: 99e6ddd8-4f94-5aeb-9310-09040d20ac31
DOI: 10.1101/2022.01.17.476677

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