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SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells

2020-08-19

Abstract excerpt

Disrupted antiviral immune responses are associated with severe COVID-19, the disease caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of the viral genome contains a putative transmembrane domain, interacts with membrane proteins in multiple cellular compartments, and impairs antiviral processes in a lung epithelial cell line. Proteomic, interactome, and transcriptomic analyses,...

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Literature Corpus work
1b400af5-dfd9-5354-bf4e-b46c5ae8b409
DOI
10.1101/2020.08.18.256776
Open publication

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SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in CellsDOI 10.1101/2020.08.18.256776
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