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Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics

3 Apr 2023

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The recent emergence of SARS-CoV-2 in the human population has caused a global pandemic. The virus encodes two proteases, M pro and PL pro, that are thought to play key roles in the suppression of host protein synthesis and immune response evasion during infection. To identify the specific host cell substrates of these proteases, active recombinant SARS-CoV-2 M...

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PMID: 37011043
DOI: 10.1021/acsinfecdis.2c00458

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