Article

Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex

2024-06-17

Abstract excerpt

<h4>Summary</h4> The human spastizin (spastic paraplegia 15, SPG15) and spatacsin (spastic paraplegia 11, SPG11) complex is involved in cargo sorting from late endosomes to the Golgi, and mutations in these two proteins are linked with hereditary autosomal recessive spastic paraplegia (HSP). SPG11-SPG15 can cooperate with evolutionarily ancient fifth adaptor protein complex (AP5). We employed cryo-electron micros...

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Literature Corpus work: 60ff9a5b-6318-5136-b0ab-8807438e88b6
DOI: 10.1101/2024.06.14.598999

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