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Article

TMEM16K is an interorganelle regulator of endosomal sorting.

Nature communications - 3 Jul 2020

Petkovic Maja, Oses-Prieto Juan, Burlingame Alma, Jan Lily Yeh, Jan Yuh Nung

Abstract excerpt

Communication between organelles is essential for their cellular homeostasis. Neurodegeneration reflects the declining ability of neurons to maintain cellular homeostasis over a lifetime, where the endolysosomal pathway plays a prominent role by regulating protein and lipid sorting and degradation. Here we report that TMEM16K, an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia...

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Identifiers

PMID: 32620747
DOI: 10.1038/s41467-020-17016-8
PMCID: PMC7335067

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