Article

Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

2017-09-25

Abstract excerpt

<h4>SUMMARY</h4> The ER is a complex network of sheets and tubules that is continuously being remodeled. The relevance of this membrane dynamics is underscored by the fact that mutations in Atlastins (ATL), the ER fusion proteins in mammals, cause neurodegeneration. How defects in this process disrupt neuronal homeostasis is largely unknown. Here we show by EM volume reconstruction of transfected cells, neurons a...

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Literature Corpus work: ea53e9a4-4e35-5309-9496-f488600aea34
DOI: 10.1101/192484

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