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Insights on autophagosome-lysosome tethering from structural and biochemical characterization of human autophagy factor EPG5.

Communications biology - 5 Mar 2021

Nam Sung-Eun, Cheung Yiu Wing Sunny, Nguyen Thanh Ngoc, Gong Michael, Chan Samuel, Lazarou Michael, Yip Calvin K

Abstract excerpt

Pivotal to the maintenance of cellular homeostasis, macroautophagy (hereafter autophagy) is an evolutionarily conserved degradation system that involves sequestration of cytoplasmic material into the double-membrane autophagosome and targeting of this transport vesicle to the lysosome/late endosome for degradation. EPG5 is a large-sized metazoan protein proposed to serve as a tethering factor to enforce...

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PMID: 33674710
DOI: 10.1038/s42003-021-01830-x
PMCID: PMC7935953

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