Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis.

Autophagy - 1 Jan 2019

Vantaggiato Chiara, Panzeri Elena, Castelli Marianna, Citterio Andrea, Arnoldi Alessia, Santorelli Filippo Maria, Liguori Rocco, Scarlato Marina, Musumeci Olimpia, Toscano Antonio, Clementi Emilio, Bassi Maria Teresa

Abstract excerpt

ZFYVE26/Spastizin and SPG11/Spatacsin encode 2 large proteins that are mutated in hereditary autosomal-recessive spastic paraplegia/paraparesis (HSP) type 15 (AR-SPG15) and type 11 (AR-SPG11), respectively. We previously have reported that AR-SPG15-related ZFYVE26 mutations lead to autophagy defects with accumulation of immature autophagosomes. ZFYVE26 and SPG11 were found to be part of a complex including the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Autophagosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Lysosomes

Share to rab GTP-Binding Proteins

Share to rab5 GTP-Binding Proteins

Share to Retinal Degeneration

Share to Spastic Paraplegia, Hereditary

Source

Open in PubMed Open full text

Identifiers

PMID: 30081747
DOI: 10.1080/15548627.2018.1507438
PMCID: PMC6287682

Genes

SPG11
ZFYVE26
ATG14
BECN1
EEA1
EGF
EGFR
RUBCN
SQSTM1
UVRAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis.PMID 30081747Read ↗

A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system.Semantic proximity Read ↗

ZFYVE26/SPASTIZIN: a close link between complicated hereditary spastic paraparesis and autophagy.Semantic proximity Read ↗

Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15.Semantic proximity Read ↗

Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformationSemantic proximity Read ↗

Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegiaSemantic proximity Read ↗

Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complexSemantic proximity Read ↗

Distant homologies and domain conservation of the Hereditary Spastic Paraplegia protein SPG11/ALS5/spatacsinSemantic proximity Read ↗

Lysosomal abnormalities in hereditary spastic paraplegia types <scp>SPG</scp> 15 and <scp>SPG</scp> 11Semantic proximity Read ↗

The role of AP-4 in cargo export from the trans-Golgi network and hereditary spastic paraplegia.Semantic proximity Read ↗

Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes.Semantic proximity Read ↗

Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolismSemantic proximity Read ↗

Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.