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Article

Genetic effects of sequence-conserved enhancer-like elements on human complex traits.

Genome biology - 2 Jan 2024

Zhu Xiang, Ma Shining, Wong Wing Hung

Abstract excerpt

BACKGROUND: The vast majority of findings from human genome-wide association studies (GWAS) map to non-coding sequences, complicating their mechanistic interpretations and clinical translations. Non-coding sequences that are evolutionarily conserved and biochemically active could offer clues to the mechanisms underpinning GWAS discoveries. However, genetic effects of such sequences have not been systematically...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 38167462
DOI: 10.1186/s13059-023-03142-1
PMCID: PMC10759394

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