Article

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

2023-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Centromere protein A (CENP-A), a histone H3 variant specific to centromeres, is crucial for kinetochore positioning and chromosome segregation. However, its regulatory mechanism in human cells remains incompletely understood. We conducted a structure-activity relationship (SAR) study of the cell cycle-arresting indole terpenoid mimic JP18 and found two more potent analogues, (+)-6-Br-JP18 and (+...

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Literature Corpus work: 60f5d4d8-66e2-57b0-a376-e3bcb37f8755
DOI: 10.1101/2023.04.25.538200

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