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Mitotic drug targets

1 Jun 2010

Abstract excerpt

Mitosis is the key event of the cell cycle during which the sister chromatids are segregated onto two daughter cells. It is well established that abrogation of the normal mitotic progression is a highly efficient concept for anti-cancer treatment. In fact, various drugs that target microtubules and thus interfere with the function of the mitotic spindle are in clinical use for the treatment of various human...

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PMID: 20518069
DOI: 10.1002/jcb.22721

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