Article
A novel compound that disrupts mitotic spindle poles in human cells
2020-08-14
Abstract excerpt
<h4>ABSTRACT</h4> We characterize the mechanism of action of a new microtubule-targeting compound in cells. Microtubule-targeting drugs are used as successful anti-cancer therapies. We synthesized a family of compounds that share a common scaffold and have several functional groups amenable to modifications. We found that one of the active derivatives, C75, reduces cell viability and prevents microtubule polymeri...
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Identifiers and source
- Literature Corpus work
- e190ebac-e1f4-531e-9a44-12123e3c2ff0
- DOI
- 10.1101/2020.08.14.251058