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Article

Tubulin-Interactive Natural Products as Anticancer Agents

6 Jan 2009

Abstract excerpt

This review provides an overview of the discovery, structures, and biological activities of anticancer natural products that act by inhibiting or promoting the assembly of tubulin to microtubules. The emphasis is on providing recent information on those compounds in clinical use or in advanced clinical trials. The vinca alkaloids, the combretastatins, NPI-2358, the halichondrin B analogue eribulin, dolastatin 10,...

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PMID: 19125622
DOI: 10.1021/np800568j

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