Article

Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis leading to rotenone-induced G2/M Arrest

2025-03-26

Abstract excerpt

Rotenone, a lipophilic pesticide, is strongly linked to dopaminergic neuronal loss in Parkinson’s disease (PD), primarily through mitochondrial complex I inhibition. While rotenone induces G2/M arrest in dividing cells, the underlying molecular events remain unclear. We identify HMGB1 as a key player in this process. HMGB1, known for its roles in genomic integrity and inflammation, exits the nucleus during rotenon...

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Literature Corpus work: 788b88b1-5a12-5796-82a7-101ed0fb3d76
DOI: 10.1101/2025.03.25.645152

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Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis leading to rotenone-induced G2/M ArrestDOI 10.1101/2025.03.25.645152Read

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