Article

Identification of a novel HASPIN inhibitor and its synergism with the PLK1 inhibitor

2022-09-07

Abstract excerpt

<h4>Background: </h4> HASPIN, a mitotic kinase for Histone H3, is a promising target for anti-cancer therapy. However, as HASPIN is an atypical kinase with low similarity to eukaryotic protein kinases, development of a HASPIN inhibitor from the conventional pharmacophore of kinase inhibitors would be technically challenging. <h4>Methods: </h4>: Chemical modifications of a cytotoxic 4’-thioadenosine analogue with h...

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Literature Corpus work: 8b0bc62a-f11c-59ee-af34-558c5e51d1a6
DOI: 10.21203/rs.3.rs-2027316/v1

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