Article

Terpyridine Platinum Compounds Induce Telomere Dysfunction and Chromosome Instability in Cancer Cells

2021-05-07

Abstract excerpt

<title>Abstract</title> <p>Background Telomerase/telomere-targeting therapy is a potentially promising approach for cancer treatment because even transient telomere dysfunction can induce chromosomal instability (CIN) and may be a barrier to tumor growth. <h4>Method:</h4> We recently developed a dual-HAC (Human Artificial Chromosome) assay that enables identification and ranking of compounds that induce CIN as a...

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Literature Corpus work: 19fd54df-47cd-5a12-9266-3c32619882de
DOI: 10.21203/rs.3.rs-417658/v1

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