Article

Identification of a novel HASPIN inhibitor and its synergism with the PLK1 inhibitor

2022-09-03

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> HASPIN, a mitotic kinase for Histone H3, is a promising target for anti-cancer therapy. However, as HASPIN is an atypical kinase with low similarity to eukaryotic protein kinases, development of a HASPIN inhibitor from the conventional pharmacophore of kinase inhibitors would be technically challenging. <h4>Methods</h4> Chemical modifications of a cytotoxic 4’-thioadenosine...

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Literature Corpus work: 13b00181-7d77-53de-b483-34d00b8bd64d
DOI: 10.1101/2022.09.01.506282

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