Article

Systems biology-driven miR-mRNA integration identifies potential steroid- refractoriness biomarkers in ulcerative colitis and reveals a conserved mechanism across species

2025-09-17

Abstract excerpt

<title>Abstract</title> <p> <bold>Background and Aims:</bold> Approximately 60% of patients with ulcerative colitis (UC) exhibit steroid resistance or dependence, highlighting the need for reliable biomarkers to predict therapeutic response. This study employed a systems biology and machine learning approach to integrate microRNA (miR) and mRNA expression data from both rectal biopsies and plasma samples from U...

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Literature Corpus work: 82c2ac45-a784-5491-837c-b8851ac56a58
DOI: 10.21203/rs.3.rs-7401947/v1

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