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Article

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease

4 Aug 2020

Abstract excerpt

integrin subunit mediated the effectiveness of anti-TNF therapy in human immune cells. Thus, TransComp-R identified an integrin signaling mechanism with potential therapeutic implications for overcoming anti-TNF therapy resistance. We suggest that TransComp-R is a generalizable framework for addressing species, molecular, and phenotypic discrepancies between model systems and patients to translationally deliver...

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PMID: 32753478
DOI: 10.1126/scisignal.aay3258

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