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Article

A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients.

Communications biology - 24 Jan 2023

Peters Lauren A, Friedman Joshua R, Stojmirovic Aleksandar, Hagen Jacob, Houten Sander, Dodatko Tetyana, Amaro Mariana P, Restrepo Paula, Chai Zhi, Rodrigo Mora J, Raymond Holly A, Curran Mark, Dobrin Radu, Das Anuk, Xiong Huabao, Schadt Eric E, Argmann Carmen, Losic Bojan

Abstract excerpt

Previous studies have conducted time course characterization of murine colitis models through transcriptional profiling of differential expression. We characterize the transcriptional landscape of acute and chronic models of dextran sodium sulfate (DSS) and adoptive transfer (AT) colitis to derive temporal gene expression and splicing signatures in blood and colonic tissue in order to capture dynamics of colitis...

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PMID: 36694043
DOI: 10.1038/s42003-023-04469-y
PMCID: PMC9873918

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