Article
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.
Progress in neurobiology - 9 Feb 2010
Schwarcz Robert, Guidetti Paolo, Sathyasaikumar Korrapati V, Muchowski Paul J
Abstract excerpt
The neurodegenerative disease Huntington's disease (HD) is caused by an expanded polyglutamine (polyQ) tract in the protein huntingtin (htt). Although the gene encoding htt was identified and cloned more than 15 years ago, and in spite of impressive efforts to unravel the mechanism(s) by which mutant htt induces nerve cell death, these studies have so far not led to a good understanding of pathophysiology or an...
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