Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular Localization of Huntingtin in Striatal and Cortical Neurons in Rats: Lack of Correlation with Neuronal Vulnerability in Huntington’s Disease

15 Feb 1999

Abstract excerpt

Immunohistochemistry and single-cell RT-PCR were used to characterize the localization of huntingtin and/or its mRNA in the major types of striatal neurons and in corticostriatal projection neurons in rats. Single-label immunohistochemical studies revealed that striatum contains scattered large neurons rich in huntingtin and more numerous medium-sized neurons moderate in huntingtin. Double-label...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Ion channel regulation and function
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9952397
DOI: 10.1523/jneurosci.19-04-01189.1999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular Localization of Huntingtin in Striatal and Cortical Neurons in Rats: Lack of Correlation with Neuronal Vulnerability in Huntington’s DiseasePMID 9952397Read ↗

Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse.Semantic proximity Read ↗

Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.Semantic proximity Read ↗

Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and SurvivalSemantic proximity Read ↗

Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.Semantic proximity Read ↗

The selective vulnerability of nerve cells in Huntington's diseaseSemantic proximity Read ↗

Synaptic Dysfunction in Huntington’s Disease: Lessons from Genetic Animal ModelsSemantic proximity Read ↗

Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington diseaseSemantic proximity Read ↗

Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s diseaseSemantic proximity Read ↗

Axonal Transport of N-terminal Huntingtin Suggests Early Pathology of Corticostriatal Projections in Huntington DiseaseSemantic proximity Read ↗

Cell type-specific localization of optineurin in the striatal neurons of mice: implications for neuronal vulnerability in Huntington's disease.Semantic proximity Read ↗

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.Semantic proximity Read ↗

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.