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Article

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation.

Brain : a journal of neurology - 1 Aug 2002

Behrens P F, Franz P, Woodman B, Lindenberg K S, Landwehrmeyer G B

Abstract excerpt

The pathogenesis of Huntington's disease is still not completely understood. Several lines of evidence from toxic/non-transgenic animal models of Huntington's disease suggest that excitotoxic mechanisms may contribute to the pathological phenotype. Evidence from transgenic animal models of Huntington's disease, however, is sparse. To explore potential alterations in brain glutamate handling we studied transgenic...

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Source

Identifiers

PMID: 12135980
DOI: 10.1093/brain/awf180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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