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Article

Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation.

Journal of neurochemistry - 1 Apr 1999

Reynolds G P, Dalton C F, Tillery C L, Mangiarini L, Davies S W, Bates G P

Abstract excerpt

Huntington's disease (HD) is associated with an expansion in the CAG repeat sequence of a gene on chromosome 4, resulting in a neurodegenerative process particularly affecting the striatum and with profound but selective changes in content of various neurotransmitters. Recently, transgenic mice expressing a fragment of the human HD gene containing a large CAG expansion have been generated; these mice exhibit a...

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PMID: 10098889
DOI: 10.1046/j.1471-4159.1999.721773.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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