Article

Gene Knock Up via 3’UTR editing to study gene function <i>in vivo</i>

2019-09-23

Abstract excerpt

Currently available genetic tools do not allow researchers to upregulate (‘Knock Up’) the levels of a given protein while retaining its cell-type-specific regulation. As a result, we have limited ability to develop overexpression-related disease models, to study the contribution of single genes in diseases caused by copy number variations and to identify disease pathways for drug targets. Here we develop two appro...

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Literature Corpus work: 60ea5ace-4d3d-5453-889f-8271389721fc
DOI: 10.1101/775031

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