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Article

Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Jiang Jie, Hu Zhengshan, Lyons Karen M

Abstract excerpt

Two developments have greatly facilitated the construction of CCN mutant mouse strains. The first is the availability of modified embryonic stem (ES) cells and mice developed through several large-scale government-sponsored research programs. The second is the advent of CRISPR/Cas9 technology. In this chapter, we describe the available mouse strains generated by gene targeting techniques and the CCN targeting...

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PMID: 27734387
DOI: 10.1007/978-1-4939-6430-7_28

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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