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Article

Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.

Molecular cell - 5 Oct 2017

Chen Ying-Chou, Farzadfard Fahim, Gharaei Nava, Chen William C W, Cao Jicong, Lu Timothy K

Abstract excerpt

The genome-wide perturbation of transcriptional networks with CRISPR-Cas technology has primarily involved systematic and targeted gene modulation. Here, we developed PRISM (Perturbing Regulatory Interactions by Synthetic Modulators), a screening platform that uses randomized CRISPR-Cas transcription factors (crisprTFs) to globally perturb transcriptional networks. By applying PRISM to a yeast model of...

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Identifiers

PMID: 28985507
DOI: 10.1016/j.molcel.2017.09.014
PMCID: PMC5702536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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