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Article

Interrogation of human microglial phagocytosis by CRISPR genome editing

7 Jul 2023

Abstract excerpt

Background Microglia are an integral part of central nervous system, but our understanding of microglial biology is limited due to the challenges in obtaining and culturing primary human microglia. HMC3 is an important cell line for studying human microglia because it is readily accessible and straightforward to maintain in standard laboratories. Although HMC3 is widely used for microglial research, a robust...

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PMID: 37483607
DOI: 10.3389/fimmu.2023.1169725

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