Article

Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling

2020-04-11

Abstract excerpt

Aberrant activation of RAS oncogenes is prevalent in lung adenocarcinoma, with somatic mutation of KRAS occurring in ∼30% of tumors. Recently, we identified somatic mutation of the RAS-family GTPase RIT1 in lung adenocarcinoma, but relatively little is known about the biological pathways regulated by RIT1 and how these relate to the oncogenic KRAS network. Here we present quantitative proteomic and transcriptomi...

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Literature Corpus work: d76ee84b-702b-5166-beb7-5ad0796e77b8
DOI: 10.1101/2020.04.10.030460

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