Article
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing.
Nature communications - 30 Jul 2021
Laliotis Georgios I, Chavdoula Evangelia, Paraskevopoulou Maria D, Kaba Abdul, La Ferlita Alessandro, Singh Satishkumar, Anastas Vollter, Nair Keith A, Orlacchio Arturo, Taraslia Vasiliki, Vlachos Ioannis, Capece Marina, Hatzigeorgiou Artemis, Palmieri Dario, Tsatsanis Christos, Alaimo Salvatore, Sehgal Lalit, Carbone David P, Coppola Vincenzo, Tsichlis Philip N
Abstract excerpt
AKT-phosphorylated IWS1 regulates alternative RNA splicing via a pathway that is active in lung cancer. RNA-seq studies in lung adenocarcinoma cells lacking phosphorylated IWS1, identified a exon 2-deficient U2AF2 splice variant. Here, we show that exon 2 inclusion in the U2AF2 mRNA is a cell cycle-dependent process that is regulated by LEDGF/SRSF1 splicing complexes, whose assembly is controlled by the IWS1...
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