Article

Identification of Subsets of Genetic Alterations in KRAS-mutant Lung Cancer using Association Rule Mining

2017-12-17

Abstract excerpt

<h4>Background</h4> Lung cancer is the leading cause of all cancer death accounting for 1 out of 4 cancer-related death in both men and women. KRAS mutations occur in ~ 25% of patients with lung cancer, and the presence of these mutations is associated with poor prognosis. Efforts to directly target KRAS or associated downstream MAPK or the PI3K/AKT/mTOR pathways have seen little or no benefits. One probable reas...

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Literature Corpus work: 5e1c7ec7-3ea2-53ca-b3d1-d3fbc4567880
DOI: 10.1101/235390

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