Article
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.
Genome research - 1 Dec 2012
Liu Jinfeng, Lee William, Jiang Zhaoshi, Chen Zhongqiang, Jhunjhunwala Suchit, Haverty Peter M, Gnad Florian, Guan Yinghui, Gilbert Houston N, Stinson Jeremy, Klijn Christiaan, Guillory Joseph, Bhatt Deepali, Vartanian Steffan, Walter Kimberly, Chan Jocelyn, Holcomb Thomas, Dijkgraaf Peter, Johnson Stephanie, Koeman Julie, Minna John D, Gazdar Adi F, Stern Howard M, Hoeflich Klaus P, Wu Thomas D, Settleman Jeff, de Sauvage Frederic J, Gentleman Robert C, Neve Richard M, Stokoe David, Modrusan Zora, Seshagiri Somasekar, Shames David S, Zhang Zemin
Abstract excerpt
Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole-genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and three lung tumor/normal pairs. Overall, our data show that cell line models exhibit similar mutation spectra to human tumor samples. Smoker and never-smoker cancer samples exhibit...
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