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Article

Healthy glucocorticoid receptor N363S carriers dysregulate gene expression associated with metabolic syndrome.

American journal of physiology. Endocrinology and metabolism - 1 Oct 2016

Jewell Christine M, Katen Kevin S, Barber Lisa M, Cannon Crystal, Garantziotis Stavros, Cidlowski John A

Abstract excerpt

The glucocorticoid receptor single-nucleotide polymorphism (SNP) N363S has been reported to be associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease. Our aim was to determine how the N363S SNP modifies glucocorticoid receptor signaling in a healthy population of individuals prior to the onset of disease. We examined the function of the N363S SNP in a cohort of subjects from the general...

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Identifiers

PMID: 27600822
DOI: 10.1152/ajpendo.00105.2016
PMCID: PMC5241554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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