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Article

Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2017

Whirledge Shannon D, Jewell Christine M, Barber Lisa M, Xu Xiaojiang, Katen Kevin S, Garantziotis Stavros, Cidlowski John A

Abstract excerpt

Alternative splicing of the human glucocorticoid receptor gene generates two isoforms, hGRα and hGRβ. hGRβ functions as a dominant-negative regulator of hGRα activity and but also has inherent transcriptional activity, collectively altering glucocorticoid sensitivity. Single-nucleotide polymorphisms in the 3' UTR of hGRβ have been associated with altered receptor protein expression, glucocorticoid sensitivity,...

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PMID: 28759007
DOI: 10.1038/labinvest.2017.76
PMCID: PMC5759773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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