Article
Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor.
Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2017
Whirledge Shannon D, Jewell Christine M, Barber Lisa M, Xu Xiaojiang, Katen Kevin S, Garantziotis Stavros, Cidlowski John A
Abstract excerpt
Alternative splicing of the human glucocorticoid receptor gene generates two isoforms, hGRα and hGRβ. hGRβ functions as a dominant-negative regulator of hGRα activity and but also has inherent transcriptional activity, collectively altering glucocorticoid sensitivity. Single-nucleotide polymorphisms in the 3' UTR of hGRβ have been associated with altered receptor protein expression, glucocorticoid sensitivity,...
Topics
- 3' Untranslated Regions
- Adult
- Amino Acid Substitution
- Black People
- Cell Line, Tumor
- Cells, Cultured
- Cohort Studies
- Female
- Gene Expression Regulation
- Genetic Association Studies