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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

2024-06-08

Abstract excerpt

Differentiation of antigen-activated B cells into pro-proliferative germinal center (GC) B cells depends on the activity of the transcription factor MYC and the epigenetic writers DOT1L and EZH2. GCB-like Diffuse Large B Cell Lymphomas (GCB-DLBCLs) arise from GC B cells and closely resemble their cell of origin. Given the dependency of GC B cells on DOT1L and EZH2, we investigated the role of these epigenetic regu...

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Literature Corpus work
60975b07-7356-5099-ade8-cafd47e95fac
DOI
10.1101/2024.06.05.597556
Open publication

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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell LymphomaDOI 10.1101/2024.06.05.597556
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