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Article

Epigenetic Mechanisms of Therapy Resistance in Diffuse Large B Cell Lymphoma (DLBCL).

Current cancer drug targets - 1 Jan 2021

Isshiki Yusuke, Melnick Ari

Abstract excerpt

Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin B cell lymphoma (NHL), and manifests highly heterogeneous genetic/phenotypic characteristics as well as variable responses to conventional immunochemotherapy. Genetic profiling of DLBCL patients has revealed highly recurrent mutations of epigenetic regulator genes such as CREBBP, KMT2D, EZH2 and TET2. These mutations...

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Topics

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Share to Antineoplastic Agents, Immunological
Share to Drug Resistance, Neoplasm
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Lymphoma Diagnosis and Treatment

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mutation

Share to Neoplasm Proteins

Source

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Identifiers

PMID: 33413063
DOI: 10.2174/1568009620666210106122750
PMCID: PMC10591517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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