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The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN

8 Aug 2025

Abstract excerpt

Persistence of JAK2-mutated clones that may undergo clonal evolution and malignant transformation remains a challenge in myeloproliferative neoplasms (MPN), Novel therapeutic approaches to attenuate clonal evolution and progression to blast-phase are therefore urgently needed. LSD1 (KDM1A) inhibitors reduce symptoms and clonal burden in MPN, but whether these compounds may be effective in advanced disease stages...

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PMID: 40781484
DOI: 10.1038/s41375-025-02719-y

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