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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma

10 Jan 2025

Abstract excerpt

ABSTRACT: Differentiation of antigen-activated B cells into proproliferative germinal center (GC) B cells depends on the activity of the transcription factors myelocytoma (MYC) and B-cell lymphoma 6 (BCL6), and the epigenetic writers disruptor of telomeric silencing 1-like (DOT1L) and enhancer of zeste homolog 2 (EZH2). GCB-like diffuse large B-cell lymphomas (GCB-DLBCLs) arise from GCB cells and closely resemble...

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PMID: 39792929
DOI: 10.1182/blood.2024025500

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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphomaPMID 39792929Read ↗

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