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Article

The epigenetic basis of diffuse large B-cell lymphoma.

Seminars in hematology - 1 Apr 2015

Jiang Yanwen, Melnick Ari

Abstract excerpt

The pathogenesis of diffuse large B-cell lymphoma (DLBCL) is strongly linked to perturbation of epigenetic mechanisms. The germinal center (GC) B cells from which DLBCLs arise are prone to instability in their cytosine methylation patterns. DLBCLs inherit this epigenetic instability and display variable degrees of epigenetic heterogeneity. Greater epigenetic heterogeneity is linked with poor clinical outcome....

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Identifiers

PMID: 25805588
DOI: 10.1053/j.seminhematol.2015.01.003
PMCID: PMC4374125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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