Article
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer cell - 11 May 2020
Béguelin Wendy, Teater Matt, Meydan Cem, Hoehn Kenneth B, Phillip Jude M, Soshnev Alexey A, Venturutti Leandro, Rivas Martín A, Calvo-Fernández María T, Gutierrez Johana, Camarillo Jeannie M, Takata Katsuyoshi, Tarte Karin, Kelleher Neil L, Steidl Christian, Mason Christopher E, Elemento Olivier, Allis C David, Kleinstein Steven H, Melnick Ari M
Abstract excerpt
Follicular lymphomas (FLs) are slow-growing, indolent tumors containing extensive follicular dendritic cell (FDC) networks and recurrent EZH2 gain-of-function mutations. Paradoxically, FLs originate from highly proliferative germinal center (GC) B cells with proliferation strictly dependent on interactions with T follicular helper cells. Herein, we show that EZH2 mutations initiate FL by attenuating GC B cell...
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