Article

WNT-driven chromosomal instability as a biomarker for PORCN inhibition

2026-04-15

Abstract excerpt

Targeting Porcupine (PORCN), a key regulator of the WNT-signalling pathway, has shown therapeutic potential in multiple cancers. Despite strong target engagement and acceptable safety profiles through human phase I clinical trials, low phase II efficacy has stalled further clinical development. Given that aberrant WNT signalling can drive tumorigenesis by inducing chromosomal instability (CIN), we hypothesised tha...

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Literature Corpus work: 608c8c36-9879-5c31-be7e-2ff464dce5b0
DOI: 10.64898/2026.04.13.718275

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