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Article

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

28 Sept 2019

Abstract excerpt

Objective Pathological Wnt pathway activation is a conserved hallmark of colorectal cancer. Wnt-activating mutations can be divided into: i) ligand-independent (LI) alterations in intracellular signal transduction proteins ( Adenomatous polyposis coli , β-catenin), causing constitutive pathway activation and ii) ligand-dependent (LD) mutations affecting the synergistic R-Spondin axis ( RNF43 , RSPO -fusions)...

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Share to Colorectal Cancer Treatments and Studies
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 31563876
DOI: 10.1136/gutjnl-2019-319126

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