Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

4 Mar 2021

Abstract excerpt

Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clinical trials. In a survey for potential combination therapies, we found that Wnt inhibition synergizes with the PARP inhibitor olaparib in Wnt‐addicted cancers....

Topics

Join the communities discussing this publication.

CRISPR and Genetic Engineering
DNA Repair Mechanisms
PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33660437
DOI: 10.15252/emmm.202013349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancerPMID 33660437Read ↗

WNT inhibition creates a BRCA-like state in Wnt-addicted cancerSemantic proximity Read ↗

Wnt Signaling and Drug Resistance in Cancer.Semantic proximity Read ↗

Wnt signaling in cancer.Semantic proximity Read ↗

Investigating the Expression Pattern, Prognostic and Immunological Significance of the WNT family in Breast CancerSemantic proximity Read ↗

Wnt signaling in cancer.Semantic proximity Read ↗

Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translationSemantic proximity Read ↗

WNT-driven chromosomal instability as a biomarker for PORCN inhibitionSemantic proximity Read ↗

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic ResponseSemantic proximity Read ↗

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and MechanismsSemantic proximity Read ↗

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?Semantic proximity Read ↗

BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer.Semantic proximity Read ↗

Pan-cancer genomic amplifications underlie a Wnt hyperactivation phenotype associated with stem cell-like features leading to poor prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.