Article
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer
2020-06-18
Abstract excerpt
<h4>ABSTRACT</h4> Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt-addicted preclinical cancer models and are in clinical trials. In a survey for potential combination therapies, we found that Wnt inhibition synergizes with the PARP inhibitor olaparib in Wnt-addicted cancers....
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Identifiers and source
- Literature Corpus work
- 9a8527c2-6770-591e-84f2-bbceac6afae2
- DOI
- 10.1101/2020.06.17.157024