Article
Distinct and common features of numerical and structural chromosomal instability across different cancer types
2021-10-16
Abstract excerpt
A large proportion of tumours is characterised by numerical or structural chromosomal instability (CIN), defined as an increased rate of gaining or losing whole chromosomes (W-CIN) or of accumulating structural aberrations (S-CIN). Both W-CIN and S-CIN are associated with tumourigenesis, cancer progression, treatment resistance and clinical outcome. Although W-CIN and S-CIN can co-occur, they are initiated by diff...
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Identifiers and source
- Literature Corpus work
- 4be5b3ee-c9ea-5825-941f-4cbc9258625b
- DOI
- 10.1101/2021.10.15.464567